I have an E350 for a tow vehicle and absolutly love it. It has the V-10 that is about bullet proof. Mine is a '97 with about 110K miles now. It will seat 12, has rear air and is beat all to hell. Just they way I want it. I remove the seats most of the time and used it to haul all sorts of materials during my home remodel. I have towed with excess of 10K# in the trailer and 1500# in the van and even after splitting the radiator open and adding 3 gal of water it never over heated or missed a beat while continuing the journy before I could replace the radiator.
I have about $6K in it after adding bilstein shocks, and a motorhome rear sway bar and replacing bushings and brakes after I got it. I want to get a 4.10 rear for it and replace the 3.73 some day.
Get 15 mpg non towing and about 10 towing. Better then my '03 Ram with the hemi. I got this after replacing the rear end in the 1/2 ton Ram twice. It had pleanty of power to tow but 1/2 ton was too lightly made for the 10K# trailer.
When it dies I will replace it with another. They are cheap. Keep in mind that the diesels in the vans are not aftercooled and make less HP then the trucks. Also, as this is a sit most of the time vehicle, I prefer gas as in my experience, diesels don’t like to sit for weeks before use.
Also, with the van you can haul the whole team around or even start your own church.
Michael