It seems to me that a reasonable test of this would be to get dyno data from a legally tweaked built engine, then swap in a plug-n-play MegaSquirt & connect the MAP sensor and get another set of dyno data. The results, including area under the curve, should be very close. A further refinement would be to revert the engine to “average” or new sensors and tweak the tune to result in an A/F match for the tweaked OE configuration. My bet is that the dyno results can be made to very closely match what I have right now. My “tune” isn’t perfect but it is pretty darn close to what one would like to have as far as A/F ratio is concerned.
The step after that would be to see what happens if you max out the MS tune. My guess is that you could improve the area under the curve by eliminating the fuel and timing pull that happens around 5k and by advancing timing. But I’m not sure how much additional performance there is to be had. It may turn out to be that the improvement isn’t all that significant.